Lesson 1
Diastereomers and Enantiomers in van’t Hoff’s Brochure 1
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Prof. McBride, J. Michael, CHEM 125a, Freshman Organic Chemistry I, Fall 2008, YALE Open Courses: Yale University, Chemistry (Accessed 13/09/2014), http://oyc.yale.edu/chemistry/chem-125a/lecture-27 License: Creative Commons BY-NC-SA It is important that chemists agree on notation and nomenclature in order to communicate molecular constitution and configuration. It is best when a diagram is as faithful as possible to the 3-dimensional shape of a molecule, but the conventional Fischer projection, which has been indispensable in understanding sugar configurations for over a century, involves highly distorted bonds. Ambiguity in diagrams or words has led to multibillion-dollar patent disputes involving popular drugs. International agreements provide descriptive, unambiguous, unique, systematic IUPAC names that are reasonably convenient for most organic molecules of modest molecular weight.


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