Lesson 1
Acidity of Carboxylic Acids 1
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Prof. McBride, J. Michael, CHEM 125a, Freshman Organic Chemistry I, Fall 2008, YALE Open Courses: Yale University, Chemistry (Accessed 12/09/2014), http://oyc.yale.edu/chemistry/chem-125a/lecture-18 License: Creative Commons BY-NC-SA This lecture analyzes three functional groups in terms of the interaction of localized atomic or pairwise orbitals. The acidity of carboxylic acids and the aggregation of methyl lithium into solvated tetramers can be understood in analogous terms. More amazing than the panoply of modern experimental and theoretical tools is that their results would not have surprised traditional organic chemists who already had developed an understanding of organic structure with much cruder tools. The next quarter of the semester is aimed at understanding how our scientific predecessors developed the structural model and nomenclature of organic chemistry that we still use.

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