Lesson 1
The Mechanism for Asymmetric Epoxidation of Olefins and the Story of Nexium 5
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Prof. McBride, J. Michael, CHEM 125a, Freshman Organic Chemistry I, Fall 2008, YALE Open Courses: Yale University, Chemistry (Accessed 14/09/2014), http://oyc.yale.edu/chemistry/chem-125a/lecture-34 License: Creative Commons BY-NC-SA Professor Barry Sharpless of Scripps describes the Nobel-prizewinning development of titanium-based catalysts for stereoselective oxidation, the mechanism of their reactions, and their use in preparing esomeprazole. Conformational energy of cyclic alkanes illustrates the use of molecular mechanics.

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