Lesson 1
Clinical Trials, Results for Esomeprazole and Omeprazole, Off-Label Use 1
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Prof. McBride, J. Michael, CHEM 125a, Freshman Organic Chemistry I, Fall 2008, YALE Open Courses: Yale University, Chemistry (Accessed 13/09/2014), http://oyc.yale.edu/chemistry/chem-125a/lecture-30 License: Creative Commons BY-NC-SA The chemical mode of action of omeprazole is expected to be insensitive to its stereochemistry, making clinical trials of the proposed virtues of a chiral switch crucial. Design of the clinical trials is discussed in the context of marketing. Otolaryngologist Dr. Dianne Duffey provides a clinician's perspective on the testing and marketing of pharmaceuticals, on the FDA approval process, on clinical trial system, on off-label uses, and on individual and institutional responsibility for evaluating pharmaceuticals.

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