Lesson 1
Topicity, Reactivity Difference, and Enzyme Specificity 5
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Prof. McBride, J. Michael, CHEM 125a, Freshman Organic Chemistry I, Fall 2008, YALE Open Courses: Yale University, Chemistry (Accessed 14/09/2014), http://oyc.yale.edu/chemistry/chem-125a/lecture-32 License: Creative Commons BY-NC-SA Why ethane has a rotational barrier is still debatable. Analyzing conformational and configurational stereotopicity relationships among constitutionally equivalent groups reveals a subtle discrimination in enzyme reactions. When Baeyer suggested strain-induced reactivity due to distorting bond angles away from those in an ideal tetrahedron, he assumed that the cyclohexane ring is flat. He was soon corrected by clever Sachse, but Sachse's weakness in rhetoric led to a quarter-century of confusion.


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